Endocrine Abstracts

Background: Testicular ultrasound (US) is routinely employed in the evaluation of reproductive and sexual function. However, its use for characteristics other than testicular volume is hampered by a lack of information on the prognostic value of its findings, that to date have only been incorporated in a score proposed by Lenz et al. in 1993.Objectives: We sought to explore whether testicular US examination can predict spermatogenesis and provid...

Endogenous TH metabolite 3-iodothyronamine (T1AM) and recently developed thyronamine-like synthetic analogues SG1 and SG2 have emerged as neuroprotective agents. Autophagy has proved to be an effective therapeutic approach for neurodegenerative diseases. Therefore we investigated whether these compounds can induce autophagy in human glioblastoma cells (U-87MG).Cultured U-87MG cells were initially treated with 1 μM T1AM, SG-1, SG-2 or vehicle for 30&...

Please Development and preliminary characterization of a simple human thyroid organoid in vitro model for thyroid metabolism investigation For decades, in vitro studies of the thyroid have relied on thyroid-derived tumor cell lines, which are limited by their undifferentiated phenotype, lack of response to TSH, and chromosomal abnormalities. A viable alternative are monolayer (2D) cultures of primary thyrocytes isolated from histologically normal thyroid glan...